Featured Methods

Genomics and Molecular Assays

Testing a subject for specific genomic biomarkers can provide insight into risks for various disease states or predict response to specific treatment approaches, and enable clinicians to provide personalized treatment. Pharmacogenomics (PGx) examines the genetic differences in drug metabolic pathways which can affect a subject’s response to therapeutics.

Central Lab Services include:

  • DNA Extractions (Concentration, Purity, Yield)
  • RNA Extraction (Concentration, Integrity, Yield)
  • Next Gen Sequencing
  • Viral Load Testing
    • Hepatitis B Virus DNA
    • Hepatitis C Virus RNA Qualitative/Quantitative
  • Companion Diagnostics

Key Instrumentation includes:

  • Abbott Molecular m2000
  • Agilent Bioanalyzer
  • Illumina MiSeqDx
  • Sponsor specific instrumentation installed for CDx studies

Medpace has a network of reference and strategic laboratory partners with extensive experience in genomic testing that provide seamless service to our clients for the following genomic and molecular testing:

  • Allele specific PCR
  • Capillary Gel Electrophoresis
  • Cytogenetics
  • dPCR
  • Gene expression and allelic load by real time PCR
  • Microarray
  • MRD by qPCR or NGS
  • Next Gen Sequencing (MiSeqDx, Ion Torrent)
  • PGx and Companion Diagnostics
  • Sanger Sequencing
  • Chromatography

    Medpace laboratories (central and bioanalytical labs) have broad experience in chromatographic assays supporting preclinical studies and Phase I-IV clinical trials.

    Laboratory Services include:

    • Bile Acids
    • Drug pharmacokinetics and metabolite profiling
    • Fatty Acid Panel
    • Hemoglobin A1c (NGSP Level 1 accredited)
    • Hormones
      • Dihydrotestosterone (DHT)
      • Estradiol/Estrone
      • Testosterone Total / Free
    • Nutritional Biomarkers
      • Alpha Carotene
      • Beta Carotene
      • Vitamin A
      • Vitamin B
      • Vitamin 25 OH D2and D3
      • Vitamin E
      • Vitamin K1 and K2
    • Retinyl Palmitate

    Key Instrumentation includes:

    • AB Sciex 4000, 5500, 5600, and 6500 LC-MS/MS
    • Shimadzu 060 LC-MS/MS
    • Shimadzu GCMS-QP2010
    • Tosoh G7
    • Tosoh G8
    • Waters AcQuity UPLC
    • Waters Xevo TQ-XS LC-MS/MS

    Learn More about Medpace Central Laboratory Capabilities