Integrated Bioanalytical Services
Leveraging state-of-the-art instrumentation, techniques, and facilities, our team of experts has experience in a broad range of small and large molecule bioanalytical and biomarker support. Working in a good laboratory practice (GLP) compliant setting, the Medpace Bioanalytical Laboratories provide method development, transfer, validation, and analysis of preclinical and clinical biological samples. We have extensive expertise in developing sensitive methods for LC-MS/MS – qualifying multiple-analytes, metabolites, prodrugs, and light- and temperature-sensitive compounds. Our discovery team regularly supports fast PK, bioavailability, and early toxicology studies.
Small Molecule
- PK Assays
- LC-MS/MS
- ICP-MS
- GC-MS
- Metabolite ID
- Biomarkers
- Dose Formulation Assays
Large Molecule
- PK Assays
- ADA Assays
- NAb Assays
- Real-Time PCR Assays
- Flow Cytometry
- Biomarkers
Instrumentation and Software
- AB Sciex 5600 High resolution QTOF LC MS/MS
- AB Sciex 6500 High sensitivity QTRAP LC MS/MS
- AB Sciex 6500+ High sensitivity LC MS/MS
- Sciex QTRAP 5500 (with Selex ION Ion Mobility)
- Sciex API 4000 LC MS/MS
- Waters Xevo TQ XS LC MS/MS
- GC MS with Headspace auto injector (Shimadzu GCMS QP2010)
- PerkinElmer ICP MS NexION 300X for Metal compounds
- UFLC Shimadzu LFLC/HPLC LC-30XR Systems (19,000 PSI)
- HPLC Shimadzu UFLC / LC-20 Systems
- Waters ACQUITY I Class UPLC (18,000 PSI)
- ELISA instruments (Biotech: Synergy H1, GIMINI XPS etc.) with Absorbance, Fluorescence, Luminescence
- ProteinSimple Jess
- GloMax Navigator with two injectors
- BSL II Cell Culture Lab with all equipment
- Meso Scale Discovery ECL: 2 MESO QuickPlex SQ 120
- Eppendorf Realplex and AriaMx Real time PCR
- Flow Cytometers (Attune Next Acoustic Focusing)
- Eppendorf automated sample preparation, including TomTec Quadra4 SPE
- Validated Watson LIMS with Validated PK Package & Phoenix WinNonlin digitally linked to Watson
- Fully Validated (IQ/OQ/PQ of Equipment and Software) Systems
Labeling, Shipping, and Storing Biological Samples Services
- Refrigerated storage (4ºC)
- Low-temperature storage (-20ºC, -70ºC, and -80ºC)
- Emergency back-up electrical and heating services
- Video security
- Onsite archive facility
- Barcoding system